European Convention for the protection of vertebrate animals used for experimental and other scientific purposes
The general principles governing the use of animals in research in the member states of the European Union. Appendix A is also known as ETS 123: Guidelines for Accommodation and Care of Animals.
OECD Test Guideline 401 was deleted in 2002: A Major Step in Animal Welfare: OECD Reached Agreement on the Abolishment of the LD50 Acute Toxicity Test
Organisation for Economic Co-Operation and Development
Three alternative methods were adopted in 2002 to replace the LD50 acute toxicity test.
Legislation on the Protection of Animals Used for Experimental Purposes
European Union legislation pertaining to the protection and welfare of animals used in scientific experiments.
International Guiding Principles for Biomedical Research Involving Animals (PDF | 140 KB)
Council for International Organizations of Medical Sciences (CIOMS).
Often referred to as the CIOMS Principles, this document provides criteria for establishing codes of practice or legislation about the use of animals in scientific research. Text of the 1985 guidelines is available here. *UPDATED
United Kingdom Animals (Scientific Procedures) Act 1986
The Stationery Office. Official Documents.
The principle United Kingdom law governing the use of animals in scientific research.
United Kingdom Code of Practice For the Housing and Care of Animals
United Kingdom. Home Office. Animals Scientific Procedures Division.
Provides specific information on the care and use of animals in scientific research.
Swedish Animal Welfare Act, Ordinance, and Regulations (PDF | 702 KB)
Swedish Animal Welfare Agency/Djurskyddsmyndigheten.
The Swedish Animal Welfare Act, Swedish Animal Welfare Ordinance, and animal welfare regulations are available here in English and Swedish.
Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation (PDF | 157 KB)
Organisation for Economic Co-Operation and Development (OECD).
This 2000 document discusses recognition and assessment of pain and distress and provides guidance on humane euthanasia. Link is in paragraph 4 - Guidance Document No.19 on “the Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluations” from 2000.
Chemicals Testing - Guidelines
Organisation for Economic Co-operation and Development.
Provides internationally agreed testing methods used by government, industry and independent laboratories to characterize potential hazards of new and existing chemical substances.