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Reduced Murine Local Lymph Node Assay
The National Toxicology Program - Interagency Center for the Evaluation of Alternative Toxicological Methods
The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), on behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), announces recommendations for the reduced murine Local Lymph Node Assay (LLNA).

AltTox.org
Humane Society of the United States and Proctor & Gamble.
The goal of this web site is to advance non-animal methods of toxicity testing through online discussion and information exchange.

Final Recommendations on In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants
The National Toxicology Program - Interagency Center for the Evaluation of Alternative Toxicological Methods
The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), on behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), announces the availability of this report that describes and evaluates four ocular toxicity test methods evaluated by ICCVAM.

Report of an ISRTP Workshop: Progress and barriers to incorporating alternative toxicological methods in the US (PDF|290 KB)
International Society of Regulatory Toxicology and Pharmacology.
The objective of this workshop [was] to explore progress to date in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs in the U.S., identify barriers to progress and explore potential bridges to facilitate overcoming such barriers. These barriers may be technical, regulatory, economic or societal. Slides and speakers notes for all presentations are also available.

Graphic depicting a human eye and danger sign

Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants
The Interagency Coordinating Committee on the Validation of Alternative Methods.
A November 2005 report on the utility of four in vitro ocular toxicity test methods.

Murine Local Lymph Node Assay (PDF|9.18 MB)
Interagency Coordinating Committee on the Validation of Alternative Methods; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.
The Murine Local Lymph Node Assay (LLNA) is an alternative test method for assessing the allergic contact dermatitis potential of chemicals.

Progress and Barriers To Incorporating Alternative Toxicological Methods in the U.S.
International Society of Regulatory Toxicology and Pharmacology.
The program and presentation slides from a 2005 workshop that examined progress and barriers to date in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs.

Sens-it-iv Project
An EU-funded research project with the goal of developing alternatives to animal testing when assessing skin or respiratory allergens.

Alternatives to Toxicity Testing in Animals: Challenges and Opportunities
DHHS. NIH. National Institute of Environmental Health Sciences.
This article, published in the free online journal Environmental Health Perspectives, discusses three elements on which the development of successful alternative methods in toxicology testing is based: an understanding of basic biology, availability of modifiable in vitro platforms, and convincing the scientific community of the purpose and validity of the alternative method.

Alternative Methods in Toxicology
Altweb.
Topics include product safety evaluation, acute toxicity testing, in vitro toxicology, acute occular irritation testing, and skin toxicology.

Regulatory Testing and Animal Welfare
Institute for Laboratory Animal Research.
This collection of journal articles discusses best practices and animal welfare issue in regards to regulatory testing and toxicology test methods.

Guinea pig in a PVC environmental enrichment tube

Alternative Approaches and Animal Use in the Pharmaceutical Industry (PPT|3.87 MB)
Europa, Gateway to the European Union.
This presentation offers a view of alternatives and the 3Rs from the research and development perspective of the pharmaceutical industry.

Alternative Methods Publications
Institute for In Vitro Sciences, Inc.
A bibliography and links to full-text documents on alternative methods in toxicology.

Alternative Methods: Toxicology In Vitro
Belgian Scientific Institute of Public Health.
Links to scientific papers on alternative toxicology methods produced by scientists at the Scientific Institute of Public Health. Also links to the division responsible for the development and validation of alternative methods for toxicity testing of chemicals.

Chemicals Testing - Guidelines
Organisation for Economic Co-operation and Development.
Provides internationally agreed testing methods used by government, industry and independent laboratories to characterize potential hazards of new and existing chemical substances.

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Last Modified: Oct 7, 2009


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			European Centre for the Validation of Alternative Methods (ECVAM)


			Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM)

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