Animal Welfare Information Center News FeedICCVAM AnnouncmentsThursday, October 9, 2014 - 13:45Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
New OECD Test Guidelines; DB-ALM Update; REACH Webinars; ASCCT Abstract Deadline Oct. 10
NEW OECD TEST GUIDELINES AVAILABLE
In late September, the OECD Council adopted three new chemical test guidelines and updates and corrections to six existing test guidelines.
The new test guidelines are Test Guideline 238, “Sediment-free Myriophyllum spicatum Toxicity Test,” Test Guideline 239, “Water-sediment Myriophyllum spicatum Toxicity Test,” and Test Guideline 489, “In vivo Mammalian Alkaline Comet Assay.” A correction was issued to Test Guideline 310, “Ready Biodegradation – CO2 in Sealed Vessels (Headspace Test),” and updates were issued for test guidelines for in vitro skin corrosion methods and four genotoxicity tests.
The new and updated test guidelines are available on the OECD website at http://www.oecd.org/chemicalsafety/oecd-test-guidelines-for-the-testing-of-chemicals26-september-2014.htm.
DB-ALM UPDATE LAUNCHED
The European Union Joint Research Centre (JRC) administers DB-ALM, a database of alternative methods for research and regulatory use. The JRC recently announced an update to DB-ALM offering a redesigned data retrieval approach with improved flexibility and support. New methods for identification of potential carcinogens, eye irritants, and skin sensitizers have also been added to the database.
DB-ALM is available at http://ecvam-dbalm.jrc.ec.europa.eu/beta/index.cfm/home/index.
PETA AND CHEMICAL WATCH PRESENT "REACH" WEBINARS
The PETA International Science Consortium, Ltd., and Chemical Watch are presenting a webinar series focused on alternative methods and testing strategies that can be used to meet REACH requirements. Topics for the webinars will include in silico tools, skin and eye irritation and corrosion, skin sensitization, and acute toxicity. Information about the webinar series is available at http://www.piscltd.org.uk/reaching-alternatives-animal-testing/.
The first webinar on October 22 will discuss the OECD QSAR toolbox and read-across, and will be presented by Drs. Grace Patlewicz (DuPont) and Mark Cronin (Liverpool John Moores University). Register for the October 22 webinar at https://www2.gotomeeting.com/register/264107922.
The second webinar on skin irritation and corrosion will take place on November 11 and will be presented by Drs. Gertrude-Emilia Costin (Institute for In Vitro Sciences) and Costanza Rovida (REACH Mastery). Register for the November 11 webinar at https://www2.gotomeeting.com/register/978779354
ASCCT EXTENDS ABSTRACT DEADLINE TO OCTOBER 10
The abstract deadline for the third Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT) has been extended to October 10. The meeting will take place on November 12 at the National Institutes of Health in Bethesda, Maryland, and the theme of the meeting is “Where Chemistry and Biology Meet: AOPs as a Framework for Advancing Toxicology.” The concept of AOPs will be explored from three different perspectives, featuring talks by Robert Kavlock of EPA, Jennie Larkin and Ajay Pillai from NIH, and Mark Cronin from Liverpool John Moores University, as well as a panel/audience discussion. A few submitted abstracts will be selected for oral presentations. The afternoon will include presentations from the Japanese Society for Alternatives to Animal Experiments and the Center for Alternatives to Animal Testing. A poster session, lunch, and a cocktail reception are included in the registration fee. Please visit www.ascctox.org for more information and a link to the registration page, or contact Erin Hill at email@example.com.
Wednesday, October 1, 2014 - 07:38USDA. APHIS. Animal Care.
USDA Animal and Plant Health Inspection Service sent this bulletin at 10/01/2014 07:02 AM EDT
Beginning Oct. 1, 2014, we at USDA Animal Care will realign our structure so we can more efficiently uphold and enforce the Animal Welfare Act and the Horse Protection Act. We are consolidating our administrative support, enhancing our accountability, improving our processes, and modernizing our operations.
Over the years, we have grown as an organization, but we have not always adapted our organizational structure to tackle our new responsibilities or meet our stakeholders’ growing expectations of us. This functional realignment creates a modern, flexible organization that will enable us to more easily grow and adapt to future changes. Our realignment also supports recommendations made by USDA’s Office of Inspector General after it conducted four audits of our organization.
The new USDA Animal Care organizational structure is composed of four main business units: Field Operations; The Collaboratory; Resource Management; and Information Technology. You can view a diagram of the new structure and find additional information at http://www.aphis.usda.gov/animal-welfare/realignment.
Some things will remain as they are now. For example, our realignment will not change how our inspectors conduct inspections of regulated facilities, and the process remains the same for concerned citizens who want to file an animal welfare complaint. Also, we encourage you to continue to communicate with the same USDA Animal Care employees as you have in the past.
If we plan to refine any procedures that might impact you, our stakeholders, we will communicate with you well in advance of any changes.
We hope that you will view our realignment as we do – as a way for us to increase our consistency and efficiency and thereby enhance our ability to protect the welfare of the animals regulated under the Animal Welfare Act and the Horse Protection Act.
ICCVAM AnnouncmentsThursday, September 25, 2014 - 15:14Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
EURL ECVAM Review of Alternatives, OECD AOP Wiki, Tox21 Data Challenge, HTS Data Viewer, Meeting Announcements and Summaries
OECD ANNOUNCES AOP WIKI
The Organisation for Economic Co-operation and Development (OECD) has launched the AOP Wiki, a resource for developing and sharing adverse outcome pathways (AOPs). The AOP Wiki is the first module of the OECD Adverse Outcome Pathways Knowledge Base, which will provide a focal point for AOP development and dissemination. Information about the AOP Wiki and a User Handbook is available on the OECD website at http://www.oecd.org/chemicalsafety/launch-adverse-outcome-pathways-knowledge-base.htm.
An overview of the AOP Wiki was presented at a workshop on “Adverse Outcome Pathways: From Research to Regulation” on September 3-5, which was organized by NICEATM and the Physicians Committee for Responsible Medicine. Materials from the workshop, including links to the plenary session videocasts and summaries of the breakout group discussions, are available on the NTP website at http://ntp.niehs.nih.gov/go/41375.
Also on the NTP website at http://ntp.niehs.nih.gov/go/41375 is a link to the Adverse Outcome Pathways Community listserv, an email list managed by NICEATM to provide information about events and activities of interest to AOP developers and users. You may also subscribe to the list on the NIH website at https://list.nih.gov/cgi-bin/wa.exe?SUBED1=AOP&X=0C98C98B03C7F721C4.
EUROPEAN CENTER RELEASES REVIEW OF ALTERNATIVE METHODS
In support of European Union legislation on safety of chemicals, the European Commission Joint Research Centre (JRC) has published a state-of-the art review of test methods and computational approaches that help promote the replacement, reduction, and refinement of animal experiments in the safety assessment of chemicals. The report "Alternative Methods for Regulatory Toxicology – A State-of-the-Art Review" focuses on "non-standard" methods, i.e. those that are not included in current regulatory guidelines. The review was prepared by JRC’s European Union Reference Laboratory for Alternatives to Animal Testing, a partner with NICEATM and ICCVAM in the International Cooperation for Alternative Test Methods.
A link to the report is available at https://ec.europa.eu/jrc/en/news/review-of-methods-to-assess-chemical-safety.
NCATS ACCEPTING SUBMISSIONS FOR 2014 TOX21 DATA CHALLENGE
The National Center for Advancing Translational Sciences (NCATS) is accepting submissions through November 14 for the 2014 Tox21 Data Challenge. The goal of the Challenge is to "crowdsource" analysis of Tox21 data by independent researchers to reveal how well they can predict compound interference in biochemical pathways using only chemical structure data. The computational models produced from the Challenge could become decision-making tools for government agencies in determining which environmental chemicals and drugs are of the greatest potential concern to human health
Information about the Challenge and a link to data downloads are available at https://tripod.nih.gov/tox21/challenge/. Challenge winners will be recognized on the NCATS website and via social media, and have an opportunity to submit a paper for publication in a special thematic issue of “Frontiers in Environmental Science.”
ICCVAM ADVISORY COMMITTEE MEETS
The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) met on September 16 at NIEHS. SACATM advises NICEATM, ICCVAM, and the NIEHS director on ICCVAM activities. At the September 16 meeting, ICCVAM members and NICEATM staff presented updates on NICEATM and ICCVAM activities and interactions, U.S. federal agency 3Rs activities, and NICEATM workshops on aquatic models, alternatives for pertussis vaccine testing, and adverse outcome pathways.
Materials from the September 16 meeting are available on the NTP website at http://ntp.niehs.nih.gov/about/org/sacatm/meetings/past/index.html. Presentations from the meeting will be posted on this page soon.
SUMMARY AVAILABLE OF WORKSHOP ON PERTUSSIS VACCINE TESTING
A summary of a recent workshop on progress towards replacing the murine histamine sensitization test for safety evaluation of pertussis vaccines is available on the NC3Rs website at http://www.nc3rs.org.uk/news/progress-and-challenges-replacement-histamine-sensitisation-test-hist. The workshop, a satellite meeting of the Ninth World Congress on Alternatives and Animal Use in the Life Sciences, was organized by NICEATM and international collaborators.
TRAINING VIDEO AVAILABLE FOR DATA VIEWER
The U.S. Environmental Protection Agency (EPA) has released the first beta version of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore in vitro high-throughput data generated by the ToxCast and Tox21 projects.
Information about the iCSS Dashboard is available at http://actor.epa.gov/actor/faces/CSSDashboardLaunch.jsp. The iCSS Dashboard is best used with the Google Chrome or Mozilla Firefox web browsers. A video tutorial for using the iCSS Dashboard is available at http://www.epa.gov/ncct/toxcast/data.html. These resources are still under development, and EPA welcomes feedback on both the iCSS Dashboard and the training video.
The second ToxCast Data Summit will take place September 29-30 at EPA in Research Triangle Park, NC. This meeting will bring together ToxCast data users to present ideas for using massive amounts of new chemical data and discuss implementation of these ideas to inform chemical policy and regulatory decisions. Information about the meeting is available at https://sites.google.com/site/toxcastdatasummit/. Preregistration for onsite attendance has closed, but information about walk-in registration and remote participation is available at https://sites.google.com/site/toxcastdatasummit/registration.
On October 1, the Scientific Liaison Coalition will host a webinar, “Progress Made on Tox21: A Framework for the Next Generation of Risk Science,” presented by Daniel Krewski. The webinar will be held from 12:00 noon to 1:30 pm EDT. Preregistration is required for this webinar and space is limited. A link to registration is available at https://aim-hq.webex.com/mw0401l/mywebex/default.do?siteurl=aim-hq.
The third Annual Meeting of the American Society for Cellular and Computational Toxicology (ASCCT) will take place on November 12 at the National Institutes of Health in Bethesda, Maryland. The theme of the meeting is “Where Chemistry and Biology Meet: AOPs as a Framework for Advancing Toxicology.” The theme of AOPs will be explored from three different perspectives, featuring talks by Robert Kavlock of EPA, Jennie Larkin and Ajay Pillai from NIH, and Mark Cronin from Liverpool John Moores University, as well as a panel/audience discussion. A few submitted abstracts will be selected for oral presentations. The afternoon will include presentations from the Japanese Society for Alternatives to Animal Experiments and the Center for Alternatives to Animal Testing. A poster session, lunch, and a cocktail reception are included in the registration fee. Please visit www.ascctox.org for more information and a link to the registration page, or contact Erin Hill at firstname.lastname@example.org. Abstracts for poster presentations will be accepted through October 10.
Registration Deadline Extended to September 30 for Symposium on Social Housing of Laboratory AnimalsThursday, September 25, 2014 - 15:08HHS. NIH. Office of Extramural Research.
Registration closes September 30, 2014. Register here.
Symposium on Social Housing of Laboratory Animals will be held October 5-6, 2014, in Denver, CO on the University of Colorado Anschutz Medical Campus. This symposium will bring together experts in animal behavior and welfare to address common issues in trying to achieve the mandate for social housing for social species. The first day will focus on nonhuman primates and the second on ruminants, rabbits, rodents and pigs. Participants will be encouraged to discuss special issues they are facing at their institutions. See details and preliminary agenda.
Support provided in part by Johns Hopkins University Center for Alternatives to Animal Testing, USDA Animal Welfare Information Center, and NIH OLAW.
Friday, September 19, 2014 - 11:39FDA. Center for Veterinary Medicine.
You may know the primary mission of the Food and Drug Administration is to promote and protect the public health—but are you aware of the important role of animals in achieving it?
Thursday, September 4, 2014 - 12:30HHS. NIH. Office of Extramural Research.
Symposium on Social Housing of Laboratory Animals will be held October 5-6, 2014, in Denver, CO on the University of Colorado Denver, Anschutz Medical campus. This symposium will bring together experts in animal behavior and welfare to address common issues in trying to achieve the mandate for social housing for social species. The first day will focus on nonhuman primates and the second on ruminants, rabbits, rodents and pigs. Participants will be encouraged to discuss special issues they are facing at their institutions. See details and preliminary agenda
Support provided in part by Johns Hopkins University Center for Alternatives to Animal Testing, USDA Animal Welfare Information Center, and NIH OLAW.
Tuesday, September 2, 2014 - 13:03FDA. Center for Veterinary Medicine.
Any pet owner who has been told their animal has cancer knows the two emotions: anxiety for the beloved pet’s life, and hope for an effective treatment. “Pets are living longer because of preventative health care. And we’re able to diagnose cancers earlier. As a result there is an increased need for better cancer treatments,” says Food and Drug Administration veterinarian Lisa Troutman.
Tuesday, September 2, 2014 - 10:26USDA. APHIS. Animal Care.
The National Institutes of Health, Office of Laboratory Animal Welfare (OLAW), has issued new guidance to research facilities funded by the U.S. Public Health Service. USDA Animal Care accepts this guidance for facilities registered under the Animal Welfare Act.
A notice published by OLAW on Aug. 26, 2014, outlines the significant changes to ongoing animal activities that will require a review by a facility's institutional animal care and use committee (IACUC).
The official OLAW guidance can be found here. Other helpful resources include: a seminar attended by OLAW, USDA Animal Care and other IACUC experts; and the public comments received in response to OLAW's request for information prior to publishing its guidance.
If you have any questions, contact OLAW's Office of Extramural Research by phone at (301) 496-7163 or email at email@example.com.
Tuesday, September 2, 2014 - 10:07FDA. Center for Veterinary Medicine.
Recall -- Firm Press Release.
FDA posts press releases and other notices of recalls and market withdrawals from the firms involved as a service to consumers, the media, and other interested parties. FDA does not endorse either the product or the company.
Tuesday, September 2, 2014 - 09:51FDA. Center for Veterinary Medicine.
The U.S. Food and Drug Administration is issuing warning letters today to companies manufacturing unapproved animal drugs to remove tear stains in dogs and cats.
Tuesday, September 2, 2014 - 10:00FDA. Center for Veterinary Medicine.
The U.S. Food and Drug Administration has completed a review of how the agency evaluates the harmful effects of chemicals in foods, cosmetics, dietary supplements, animal food/feed and veterinary drugs. Based on the findings, the agency is taking steps to strengthen internal processes.
Thursday, August 28, 2014 - 10:13FDA. Center for Veterinary Medicine.
Today, Mars Petcare US announced a voluntary recall of 22 bags of PEDIGREE® Adult Complete Nutrition dry dog food products due to the possible presence of a foreign material. The bags were produced in one manufacturing facility, and shipped to one retail customer. The facility production line has been shut down until this issue is resolved.
Tuesday, August 19, 2014 - 10:06USDA. APHIS. Animal Care
WASHINGTON, Aug. 15, 2014—The U.S. Department of Agriculture’s (USDA) Animal and Plant Health Inspection Service (APHIS) has amended Animal Welfare Act (AWA) regulations to require that dogs imported to the U.S. meet stronger health and safety standards to protect Americans and Americans’ pets. The new rule ensures that dogs imported for resale are vaccinated and in good health, and required to be over six months of age.
The new regulations are authorized under section 18 of the AWA, which Congress added in the 2008 Farm Bill. In September 2011, APHIS published and took comments on a proposed rule in the Federal Register addressing the requirements of the new section of the AWA.
“This rule implements new requirements in the Animal Welfare Act to ensure dogs imported for resale are healthy and vaccinated,” said Kevin Shea, Administrator for APHIS. “This will help safeguard the imported dogs, the public, and our pets and other animals.”
The final rule applies to dogs imported into the continental U.S., (including Alaska) and Hawaii, from other countries and from U.S. territories to the continental U.S.
This final rule applies to dogs intended for resale. It does not apply to dogs that are imported for research purposes, veterinary medical treatment, or for personal companions.
With Agriculture Secretary Vilsack’s leadership, APHIS works tirelessly to create and sustain opportunities for America’s farmers, ranchers and producers. Each day, APHIS promotes U.S. agricultural health, regulates genetically engineered organisms, administers the Animal Welfare Act, and carries out wildlife damage management activities, all to help safeguard the nation’s agriculture, fishing and forestry industries. In the event that a pest or disease of concern is detected, APHIS implements emergency protocols and partners with affected states and other countries to quickly manage or eradicate the outbreak. To promote the health of U.S. agriculture in the international trade arena, APHIS develops and advances science-based standards with trading partners to ensure America’s agricultural exports, valued at more than $137 billion annually, are protected from unjustified restrictions.
AOP Workshop Abstract Deadline, PBPK Modeling Course, USDA Training on Alternatives, ASCCT Annual MeetingThursday, July 24, 2014 - 08:21Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
ADVERSE OUTCOME PATHWAY WORKSHOP: ABSTRACTS AND APPLICATIONS FOR TRAINEE TRAVEL SUPPORT DUE JULY 25
Scientific poster abstracts for the upcoming workshop “Adverse Outcome Pathways: From Research to Regulation” are due by close of business on Friday, July 25. Posters should address how adverse outcome pathways may be developed or used (i) to predict toxic effects in humans or ecological systems or (ii) to improve regulatory assessment of chemical toxicity. Posters that address related issues or topics may be considered as space allows. Applications for travel support by students or postdoc presenters are also due July 25.
Submit poster abstracts and applications for travel support by email to Michael Paris (firstname.lastname@example.org). The corresponding author will be notified of an abstract’s acceptance and provided with guidelines for poster presentation by August 4. Travel support awardees will be notified by August 5. Information on abstract submission, travel support competition, and links to registration are available at http://ntp.niehs.nih.gov/go/41374.
The workshop will be held September 3-5 at the William H. Natcher Conference Center at the National Institutes of Health in Bethesda, Maryland. It is open to the public free of charge with attendance limited only by the space available. The plenary sessions of the workshop will be webcast. Individuals who plan to attend in person or view the webcast should register by August 15.
THE HAMNER INSTITUTES TO OFFER COURSE ON PBPK MODELING IN SEPTEMBER
The Hamner Institutes for Health Sciences is offering a one-week course on the principles of physiologically based pharmacokinetic (PBPK) modeling and the application of this technique in risk assessment, drug development, in vitro to in vivo extrapolation (IVIVE), and estimation of exposures from human biomonitoring data. The course features comprehensive lectures and extensive hands-on computer modeling practice. Students completing this course can earn up to 30 hours of American Board of Industrial Hygiene Certification Maintenance credit.
The course will be offered September 22-26 at the Hamner Institutes in Research Triangle Park, NC. More information and a link to registration are available at http://www.thehamner.org/about-the-hamner/education-training/pbpk-modeling/. Registration closes September 12.
USDA OFFERS TRAINING ON SEARCHING FOR ALTERNATIVES
USDA’s Animal Welfare Information Center (AWIC) holds free workshops at the National Agricultural Library to help researchers explore alternatives to procedures that may cause pain or distress to their animals. Training is targeted to principal investigators, IACUC members, administrators of animal use programs, veterinarians, librarians, and other information specialists. The workshops provide an overview of relevant topics and resources, instruction on the use of existing databases and websites, and hands-on practice conducting online database searches.
Registration is open for the next workshop, which takes place Nov. 12-14, 2014. Registration is available at http://awic.nal.usda.gov/awic-workshop-registration; workshops are limited to 20 participants.
AWIC staff members are also available to also to provide training at your institution or conduct training via webinar. Please contact AWIC at 301-504-6212 or at email@example.com for more information.
THIRD ASCCT ANNUAL MEETING TO BE HELD NOVEMBER 12
The theme of the third Annual Meeting of the American Society for Cellular and Computational Toxicology is “Where Chemistry and Biology Meet: AOPs as a Framework for Advancing Toxicology.” Dr. Robert Kavlock, Deputy Assistant Administrator for Science and interim Science Advisor at the U.S. Environmental Protection Agency, will deliver a plenary lecture on adverse outcome pathways. Other invited speakers will discuss computational toxicity tools based on AOPs for liver toxicity and the National Institutes of Health (NIH) Big Data to Knowledge initiative.
The meeting will be held November 12th in the National Library of Medicine Lister Hill Auditorium on the NIH campus in Bethesda, MD. Registration is $75 and includes lunch and a reception. Abstracts for poster presentations should be submitted to ASCCT secretary Kristie Sullivan at KSullivan@ascctox.org by September 26; a small number of abstracts will be selected for oral presentations. More information is available at http://events.r20.constantcontact.com/register/event?oeidk=a07e9dcj6fsa877545d&llr=pbddrfdab.
Considering alternatives? Attend an AWIC workshop on meeting the information requirements of the Animal Welfare ActThursday, July 3, 2014 - 09:53USDA. ARS. NAL. Animal Welfare Information Center.
Thursday, March 13, 2014 - 13:22USDA. APHIS. Animal Care.
The U.S. Department of Agriculture’s Animal and Plant Health Inspection Service (APHIS) is continuing to move swiftly and consistently to take enforcement action in response to animal welfare violations. As part of its effort to make its actions transparent and accessible to the public, APHIS is highlighting enforcement actions taken in response to violations of the Animal Welfare Act (AWA) and Horse Protection Act (HPA).
Thursday, March 13, 2014 - 09:31USDA. APHIS. Wildlife Services.
Taking on an adult grizzly bear or a pack of wolves is a lot to ask of a livestock protection dog, but it’s a task they willingly take to protect their herds from predation. For centuries, livestock protection dogs have helped ranchers protect livestock from coyotes, feral dogs, foxes, and mountain lions. Without them, thousands of sheep, lambs, and calves would be killed or injured each year.
Thursday, March 13, 2014 - 09:27USDA. APHIS. Animal Care.
USDA Animal Care has revised its factsheet entitled Questions and Answers: Regulation of Dog/Cat Breeders and Dealers.
This factsheet provides information that we hope you find useful, including: 1) the types of dog/cat breeders and dealers regulated under the Animal Welfare Act; 2) the standards of care required by USDA; and 3) USDA’s role in the commercial transport of dogs/cats.